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Tianjin CanSino produces the adenovirus vaccine type for a vaccination program of one dose and Anhui Zhifei produces the recombinant protein vaccine type for a vaccination program of three doses at intervals of 1 month (12). After the administration of the inactivated vaccine, the GMC of neutralizing antibodies decreased from 50.2 IU/mL on day 30 to 17.7 IU/mL (average decrease: 32.3%) and 13.3 IU/mL (average decrease: 25.9%) on days 180 and 240, respectively, representing an average monthly decrease of 10.1% (Figure2B). This study was a multicenter, longitudinal, prospective, observational study conducted in two hospitals (Henan Provincial Peoples Hospital and Zhengzhou Municipal Chinese Medicine Hospital) and one institution (Henan Electric Power Survey and Design Institute) in central China. Table3 Factors associated with the levels of interferon-gamma after the administration of the Chinese inactivated COVID-19 vaccine. 1:38 Syncope following injection 2:36 Primarily headaches 3:37 Clotting disorder after vaccination 4:37 Any neurological events 4:50 Dexamethasone and surgical site infection 5:51 Also had people. At intervals of 2 months, 8 mL of blood samples was collected from volunteers and distributed into four tubes (2 mL/tube) with or without the EDTA anticoagulant (two tubes for each) to detect neutralizing antibodies and cellular immune response parameters. Opens in a new tab or window, Share on Twitter. Based on our research, we rate FALSE the claim that 1 million "COVID-vaccine injuries" are reported in a CDC database. Saur D, ORyan M, Torres JP, Zuniga M, Santelices E, Basso LJ. All participants provided their informed consent in writing before enrollment. Bestlifeonline.com is part of the Meredith Health Group. The chances of any of these side effects occurring after vaccination differ according to the specific vaccine. Furthermore, this study was the first to explore the association between the blood type of participants and humoral and cellular immune responses within 240 days after the administration of a Chinese inactivated vaccine. Clinics (Sao Paulo). B pos, B Neg Blood Type Explained - Red Cross Blood Safety definitions and a list of solicited adverse events were defined as previously described (16, 17). doi:10.1016/S1473-3099(21)00479-5, 17. "The smaller sample sizes and retrospective, observational nature of many prior studies, in addition to their striking heterogeneity of ABO associations with disease susceptibility and severity, could be due to chance variations, publication bias, differences in genetic background, geography and environment, and viral strains," they wrote. Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days . The patients/participants provided their written informed consent to participate in this study. Neurological side effects occur with any of the approved vaccines but VST particularly occurs after vaccination with vector-based vaccines. The number of participants was relatively small, and at the time of the clinical study design, the administrators did not advocate the administration of vaccines from different manufacturers for separate doses. The discovery of Type Os protective effect is crucial to building an understanding of how the virus works. Medpage Today is among the federally registered trademarks of MedPage Today, LLC and may not be used by third parties without explicit permission. Additional research and review papers have confirmed that we're in more or less the same place: It looks like there really is an association between Type A blood and susceptibility to Covid and Type O blood and less susceptibility. Lustig Y, Sapir E, Regev-Yochay G, Cohen C, Fluss R, Olmer L, et al. Side Effects of COVID-19 Vaccines - World Health Organization Reactogenicity analysis results are presented as percentage of participants. Participants with an interval of <40 days between the doses of vaccination had lower levels of neutralizing antibodies than those with an interval of >40 days between the doses (B = 0.015 (0.010.021), 95% CI 0.010.021; p < 0.001) (Figure2E; Table2, and Table S3). COVID-19 Vaccine FAQ: Safety, Side Effects, Efficacy - WebMD Unfortunately, to date, occupation- and blood type-disaggregated data on cellular and humoral immunogenicity have not been reported by studies on COVID-19 vaccines. ABO blood typing was performed using a test-tube method according to the manufacturers protocol (Chengdu Xiehe Ltd., Co., Chengdu, China). Some women who received a Covid-19 vaccines have reported irregularities in their period following the shot, including heavier bleeding. Adverse reactions were mild or moderate and self-limited, with no serious events reported. The question of a possible relationship between blood type and disease risk has been a topic of active research since early in the pandemic. The first hint of a possible relationship came in March, from researchers in China, who compared nearly 2,200 hospitalized COVID-19 patients to a control group of approximately 27,000 healthy individuals. The original contributions presented in the study are included in the article/Supplementary Material. But theres another interesting layer to a potential protective element in Type O blood: something called von Willebrand factor, which is a glycoprotein in charge of repairing damage to blood vessels by prompting your blood to clot. These include anaphylaxis, a severe reaction . Then, a study published in the New England Journal of Medicine confirmed the idea with a peer-reviewed study: Folks with Type A blood were 45 percent more likely to become infected with Covid than those with other blood types, while those with Type O were 35 percent less likely. Possible Side Effects After Getting a COVID-19 Vaccine | CDC Characteristics of humoral and cellular responses to coronavirus We know the Covid virus damages the lining of your blood vessels. However, the incidence of fever, injection site pain, and malaise in the mixed-manufacturer vaccination group was slightly but significantly (p < 0.01) higher (1/143, 0.71%) than in the same-manufacturer vaccination group (1/425, 0.28; Figure2F). This weird trivia you didn't know about the world will blow you away. What are the long-term side effects of COVID vaccines? 3 - UAB Reporter The Public Health Agency of Canada, Health Canada, and provincial and territorial health authorities continue to: As of Dec. 24, there were more than 700,000 reports of adverse events . The blood group A was statistically significantly more frequent among those infected with COVID-19 compared to controls (57% vs. 38%, P < 0.001; OR: 2.1). This narrative review was conducted to collect and discuss published data about neurological side effects of SARS-CoV-2 vaccines in order to discover type, frequency, treatment, and outcome of these side effects. Bethesda, MD 20894, Web Policies Therefore, the objective of this study was to evaluate the cellular immune responses and neutralizing antibody kinetics of homologous and heterologous administrations of an inactivated coronavirus disease 2019 (COVID-19) vaccine 240 days after the second vaccination. The site is secure. The effects of blood group types on the risk of COVID-19 - PubMed Case Rep Infect Dis. O is the most common blood type in the U.S.: 37 percent of white Americans fall into this category, according to the American Red Cross, with the numbers rising to 47 percent among African-Americans, 53 percent among Latinx-Americans, and 39 percent of Asian-Americans. To date, most of the Chinese population has been vaccinated with the inactivated vaccine. doi:10.1080/14760584.2021.1971523, 13. Type O blood, the most common in the U.S., provides some protection against COVID. If you are hesitant because of the possibility of COVID vaccine side effects, the good news is, the risk of a severe reaction is low andDr. Possible side effects: Pain, redness, or swelling at the site where the shot was administered, and/or tiredness, headache, muscle pain, chills, fever, or nausea throughout the rest of the body. It is suggested that pain in the application area is the most frequent side effect among workers in a Mexican hospital who received the Pfizer BioNTech vaccine against COVID-19. and transmitted securely. 36 COVID-19 vaccine recipients develop rare blood disorder after getting Moderna, Pfizer shots Immune thrombocytopenia is a condition that causes your platelet count to fall. Research is still finding clues about who's more susceptible and why. According to Public Health England, most side-effects from two Covid vaccines - Pfizer/BioNTech and Oxford/AstraZeneca - are mild and short-lived. This "Covid arm" rash can be red, itchy, swollen, or painful. Just because youre Type O doesnt mean youre in the clear. Safety of COVID-19 Vaccines Some people have no side effects. Those who are O-negative may be the least likely to get COVID. Why women are bearing the brunt of COVID-19 vaccine side effects Hermel DJ, Spierling Bagsic SR, Costantini CL, Mason JR, Gahvari ZJ, Saven A. ABO phenotype and clinical correlates of COVID-19 severity in hospitalized patients. Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19. No use, distribution or reproduction is permitted which does not comply with these terms. FOIA Because each set underwent nine comparisons, significance for individual comparisons was set at P=0.006, meaning none of these associations were significant, they wrote in JAMA Network Open. What's your blood type? It may affect your risk for Covid-19 - NBC News The Link Between Blood Type and COVID-19 Risk - Health doi:10.1016/j.jclinepi.2021.12.015, 4. In China, the latter three have been approved and are produced by eight manufacturers. Latest research and advice on side effects and allergic reactions related to COVID-19 vaccines. Clipboard, Search History, and several other advanced features are temporarily unavailable. Pfizer vs. Moderna Vaccines: Does One Have More Side Effects? - NBC Chicago Are the Vaccines Safe? Guillain-Barre syndrome should be monitored upon mass vaccination against SARS-CoV-2. Between June 19, 2021 and April 30, 2022, healthy or clinically stable adults (aged 1880 years) who had received two doses of the inactivated COVID-19 vaccine between 3 and 8 weeks (2156 days) before the screening visit were recruited. The log-transformed level of interferon-gamma, CD4+ T-cell count, B-lymphocyte count, and IL-6 level were used as independent variables. The https:// ensures that you are connecting to the 2021 Nov 15;360:577703. doi: 10.1016/j.jneuroim.2021.577703. The multiple linear regression analysis revealed that participants aged >50 years had lower reactive IFN- levels and B-lymphocyte counts than those aged 1830 years (Tables36, Figures3AG; Tables S8S15) (B = 0.15, p = 0.03; B = 0.04, p = 0.036, respectively) (Tables3, 5; Figures3A, D). This may be due to the increased exposure of medical staff to patients with COVID-19 compared to people in other occupations. Three things to know about the long-term side effects of COVID vaccines Molly Walker is deputy managing editor and covers infectious diseases for MedPage Today. Following vaccination, the participating medical staff of Henan Provincial Peoples Hospital and Zhengzhou Municipal Traditional Medicine Hospital, and workers of the Henan Electric Power Exploration Company in central China were followed up monthly for 8 months between June 19, 2021, and April 30, 2022. In 2020, scientists started talking about a link between blood type and Covid. -, Finsterer J, Scorza FA. We thank all study participants, the Henan Provincial Peoples Hospital data safety monitoring board, and the study-steering committee. (BE) Kinetics of neutralizing antibodies according to (B) vaccination type, (C) age, (D) occupation, and (E) sex. Expert Rev Vaccines (2021) 20:13617. But VWF also encourages clotting. Because these detected records included missing data for neutralizing antibodies and cellular immune responses, we used mixed linear models that can handle unequal numbers of repeated observations for individuals when there were random missing data. dvelopper et amliorer nos produits et services. Epub 2021 May 25. 2022 Feb;29(2):555-563. doi: 10.1111/ene.15147. All analyses, including linear regression, linear mixed models, and adverse effect analysis, were conducted using SPSS 25.0 (IBM Corporation, Armonk, NY, USA) and plotted using Prism 8.0. This can progress to affect the rest of the body and cause. (19, 20), we divided participants into three BMI groups: <18.5, 18.523.9, and >23.9 kg/cm2. mRNA Based-Covid-19 Vaccine Effects on Blood Glucose Levels Some research findings have suggested that people with blood types A and AB are more susceptible to contracting COVID-19,. Second, the reported adverse events could also have been underestimated due to the small number of participants and short observation period. COVID-19 vaccine guidelines was numerous in quantity but many lack transparent reporting of methodological practices. Bivalent COVID-19 Booster Vaccine: 8 Common Side Effects 2022 Dec 6;10(34):12617-12622. doi: 10.12998/wjcc.v10.i34.12617. Experts say more . But let's back up first. COVID-19: Vaccine safety and side effects - Canada.ca COVID Vaccine Side Effects | Johns Hopkins Medicine Neutralizing antibodies, interferon-gamma (IFN-), interleukin (IL)-6, CD4+ T-lymphocyte, and B-lymphocyte counts were evaluated in serum samples after stimulation with 2 g/mL SARS-CoV-2 spike protein for 16h at follow-up intervals of 2 months. The full eligibility criteria were provided in the volunteer recruitment notification distributed through social networks, including WeChat groups. It shows the vaccine is teaching your body's immune system how to protect itself from the disease. SARS-CoV-2 vaccinations may not only be complicated by GBS but also by distal small fibre neuropathy. The following outcomes were selected and defined by the authors based on information from regulatory authorities, previous studies, large-scale adverse events initiatives: febrile seizure, aseptic. COVID Vaccine Side Effects: Here's Why Some People Suffer Severe Side Lancet Respir Med (2021) 9:9991009. Parameters of cell immune responses were evaluated by quantifying the levels of interferon (IFN)-, interleukin (IL)-6, and CD4, and counts of B-lymphocyte subsets in the plasma after overnight stimulation of whole blood with 2 g/mL SARS-CoV-2 spike peptides (Wuhan Huamei Biotechnology Ltd., Co., Wuhan, China) or dimethyl sulfoxide in whole-blood culture as a control, requiring only 2 mL blood (14). There's no known connection between blood types and side effects from COVID-19 vaccines. Heterologous versus homologous COVID-19 booster vaccination in previous recipients of two doses of CoronaVac COVID-19 vaccine in Brazil (RHH-001): A phase 4, non-inferiority, single blind, randomised study. In cases of severe adverse events, the investigator contacted the participant, and the intensity of adverse events was graded according to the adverse events severity scale as follows: 1, mild; 2, moderate; 3, severe; or 4, life-threatening. Wang Z, Liu H, Li Y, Luo X, Yang N, Lv M, et al. You've read a lot about what puts you at an increased risk of having a severe case of COVID-19, from smoking to carrying around extra weight to being over a certain age. xhr.send(payload); Novavax COVID-19 Vaccine Less Likely to Cause Side Effects Common side effects include fatigue and headache. Molly Walker, Associate Editor, MedPage Today In the case of the two mRNA COVID-19 vaccines, well over 90% of . Table2 Factors associated with the neutralization antibody concentration after the administration of the Chinese inactivated COVID-19 vaccine. Covid-19 Vaccine Side Effects Vary by Type, Remain Mild The signs are trouble breathing, swelling of the face and throat, rash, and low blood pressure. Some people with COVID-19 develop abnormal blood clots, including in the smallest blood vessels. The virus can lead to pneumonia, respiratory failure, heart problems, liver problems, septic shock, and death. According to a CDC study which analyzed the first month of vaccinations, more than 79% of side effects were reported by women, even though women only accounted for 60% of vaccinations given.. What to Know About Covid and Blood Type - Why Type O May Protect You (EG) Kinetics of interferon (IL)-6 levels according to (E) age, (F) vaccine manufacturer, (G) occupation and (H) interval between doses of vaccination. Women had 6.5 IU more neutralizing antibodies than men (B = 0.7, 95% CI 0.111.28; p = 0.021; least-square mean difference = 6.5, 95% CI 5.110.1, p = 0.019) 240 days after vaccination (Table S1). INTRODUCTION The goal of this study was to evaluate the side effects of application of the Pfizer BioNTech vaccine on the workers at a Mexican hospital. Lancet Infect Dis (2022) 22:5663. Among those who had COVID-19, hospitalization and ICU admission was associated with male sex and age. The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. And for more on the latest COVID-19 news, find out How Likely You Are to Catch COVID in the Next Month, Expert Says. xhr.open('POST', 'https://www.google-analytics.com/collect', true); Figure1 Study profile. It's normal to experience side effects after the vaccine. Eur J Med Res. Kaulen LD, Doubrovinskaia S, Mooshage C, Jordan B, Purrucker J, Haubner C, Seliger C, Lorenz HM, Nagel S, Wildemann B, Bendszus M, Wick W, Schnenberger S. Eur J Neurol. World J Clin Cases. Does Large Study Slam Door on Blood Type-COVID Link? We also evaluated CD4+ T-lymphocyte counts, B-cell counts, and IFN- and IL-6 levels after stimulation with the S protein of SARS-CoV-2 in 543, 539, 513, and 512 individuals, respectively. Future Sci OA (2021) 7:FSO735. Side effects of the Pfizer BioNTech vaccine in health workers of a But the seemingly-banal detail might be a factor in who is most susceptible to Covid 19. Lancet (2022) 399:5219. But recently, the genetics company 23andMe revealed preliminary data from their own study showing that a person's blood type, which is determined by the ABO gene, appears to affect susceptibility to coronavirus. An official website of the United States government. Based on the duration after vaccination of the participants, we divided the duration after vaccination of the participants into eight groups: 114, 1530, 3060, 6190, 91120, 121150,151180, and 181240 days. Additional . In conclusion, safety concerns against SARS-CoV-2 vaccines are backed by an increasing number of studies reporting neurological side effects. 20052022 MedPage Today, LLC, a Ziff Davis company. Nausea. Blood type could be linked to Covid-19 risk and severity, new - CNN In fact, most people dont even know whether theyre Type A, B, AB, or O. Based on their age, we divided the participants into three groups, namely, 1830, 3150, and >50 years old. Tenforde MW, Self WH, Adams K, Gaglani M, Ginde AA, McNeal T, et al. Side effects after getting a #COVID19 vaccine are normal signs your body is building protection. Our team of editors strives to be objective, unbiased, and honest. The two tubes with the EDTA anticoagulant were used to determine lymphocyte subsets with or without antigen-stimulated SARS-CoV-2 spike peptides, and the two tubes without the EDTA anticoagulant were used to determine neutralizing antibodies against SARS-CoV-2 and cytokines with or without antigen-stimulated SARS-CoV-2 spike peptides. The American Red Cross reports that 8 percent of white Americans, 4 percent of African-Americans, 4 percent of Latinx-Americans, and 1 percent of Asian-Americans are O-negative. eCollection 2021. The duration of the immune response was determined for each participant as the time interval between the date of blood collection and that of the second dose of the vaccine. The levels of cellular immune molecules, such as IFN- and CD4+ T-lymphocytes, reflect the levels of effector molecules involved in the humoral immune response, such as memory B cells and neutralizing antibodies (26). Moderna COVID-19 Vaccine Side Effects - Drugs.com Blood type, the researchers found, stood out as a potential key difference between the two groups. O and Rh-negative blood types may already have COVID-19 antibodies. This work was supported by the Henan Provincial Key Programs in Science and Technology [grant numbers 202102310355 and 182102311241] to YY and WY, and the Joint Program of Medical Science and Technology Research of Henan Province [grant numbers SB 201903018, LHGJ 20190611, and LHGJ 20200016] to YY and BW. "Given the large and prospective nature of our study and its strongly null results, we believe that important associations of SARS-CoV-2 and COVID-19 with ABO groups are unlikely and will not be useful factors associated with disease susceptibility or severity on either an individual or population level for similar environments and ancestries," they concluded. Neutralizing antibody levels were associated with a 33.89% decrease in anti-SARS-CoV-2 spike protein IgG standardized ELISA titers 180 days after the second vaccination (21), similar to our results, that is, a 32.3% decrease in neutralizing antibody levels in the following 180 days. Recombinant protein subunit vaccine booster following two-dose inactivated vaccines dramatically enhanced anti-RBD responses and neutralizing titers against SARS-CoV-2 and variants of concern. This is why some vaccines require a brief observation period after your shot. We identified age as a contributing factor; with increasing age, the antibody concentration generated was decreased, and the rate of decrease in the neutralizing antibody concentration was rapid (age 3150 years vs. age 1830 years, B = 0.31, 95% CI 0.5 to 0.1; p = 0.009; Table2; Figure2C). Unauthorized use of these marks is strictly prohibited. Associations were observed between blood type and production of neutralizing antibodies and IFN-. Thiruvengadam R, Awasthi A, Medigeshi G, Bhattacharya S, Mani S, Sivasubbu S, et al. Front Public Health. In both intervention and control groups, the positive rate of neutralizing IgG antibodies specific to the SARS-CoV-2 RBD slowly increased to 84.1% from 1 to 14 days, peaked at 97.7% from 60 to 90 days, and then slowly decreased and remained at 82.9% from 180 to 240 days after the second vaccination. Neurological autoimmune diseases following vaccinations against SARS-CoV-2: a case series. Zietz M, Zucker J, Tatonetti NP. The median age at vaccination was 35 years (interquartile range [IQR]: 2850) for those administered a vaccine of the same manufacturer (control) and 33 years (IQR: 2150) for those administered vaccines from different manufacturers (intervention) (Table1). What are the vaccines' side effects? - Mayo Clinic - Mayo Clinic Rachael Schultz is a freelance writer who focuses primarily on why our bodies and brains work the way they do, and how we can optimize both (without losing our sanity). (A) Positive rates of neutralizing antibodies. The platelets, which normally promote wound healing, end up clumping and causing blood.